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KMID : 0363220080460030418
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Korean Journal of Dermatology
2008 Volume.46 No. 3 p.418 ~ p.420
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A Case of Acral Erythema Induced by Etoposide
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Jeon Eun-Kyung
Kim Yu-Jin
Lee Young
Seo Young-Joon
Park Jang-Kyu
Lee Jeung-Hoon
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Abstract
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Etoposide is a semi-synthetic podophyllotoxin that binds to microtubular proteins to inhibit cell division. It has been used extensively in the treatment of both solid and hematologic malignancies. Chemotherapy-induced acral erythema is a distinctive syndrome of painful, symmetric, well-defined swelling and erythema of the palms and soles seen in patients receiving high-dose chemotherapy. It occurs most commonly with fluorouracil, doxorubicin, and especially cytosine arabinoside. Although etoposide, mercaptopurine and methotrexate have also been implicated. Here we report a case of acral erythema induced by etoposide in a 15-year-old child with neuroblastoma. (Korean J Dermatol 2008;46(3):418∼420)
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KEYWORD
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Acral erythema, Etoposide
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